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Publications

  1. Kohl MP,  Bahena-Ceron R, Chane-Woon-Ming B, Kompatscher M, Erlacher MD, Barchet C, von Loeffelholz O, Romby BP, Marzi S (2026). Extended Shine-Dalgarno motifs govern translation initiation in Staphylococcus aureus. Nature Communications, doi: 10.1038/s41467-026-69079-8
  2. Delazer I, Bauer I, Rummel T, Nykiel K, Rieder D, Fickl M, Tumler V, Razkova A, Schaefer MR, Scheed T, Erlacher MD, Erhard F, Micura R, Lusser A (2025). mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2. Nucleic Acids Res, doi: 10.1093/nar/gkaf995
  3. Bartuli J, Jungwirth S, Dixit M, Okuda T, Zimmermann J, Erlacher MD, Pan T, Volz A, Hüttenhofer A, Warscheid B, Höbartner C, Fischer U (2025). tRNA as an assembly chaperone for a macromolecular transcription-processing complex. Nature Structural and Molecular Biology, doi: 10.1038/s41594-025-01653-y
  4. Kompatscher M, Gonnella I, Erlacher MD (2025). Studying the Function of tRNA Modifications: Experimental Challenges and Opportunities. J Mol Biol, doi: 10.1016/j.jmb.2024.168934
  5. Safari MS, Woerl P, Garmsiri C, Weber D, Kwiatkowski M, Hotze M, Kuenkel L, Lang L, Erlacher MD, Gelpi E, Hainfellner JA, Baier G, Baier-Bitterlich G, Zur Nedden S (2024). Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake. Molecular Metabolism, doi: 10.1016/j.molmet.2024.102018
  6. Kompatscher M, Bartosik K, Erharter K, Plangger R, Juen F, Kreutz C, Micura R, Westhof E, Erlacher MD (2024). Contribution of tRNA sequences and modifications to the decoding preferences of E. coli and M. mycoides tRNAGlyUCC for synonymous glycine codons. Nucleic Acids Res, doi: 10.1093/nar/gkad1136
  7. Kohl MP, Kompatscher M, Clementi N, Holl L, Erlacher MD (2023). Initiation at AUGUG and GUGUG sequences can lead to translation of overlapping reading frames in E. coli. Nucleic Acids Res, doi: 10.1093/nar/gkac1175
  8. Vietor I, Cikes D, Piironen K, Vasakou T, Heimdoerfer D, Gstir R, Erlacher MD, Tancevski I, Eller P, Demetz E, Hess M, Kuhn V, Degenhart G, Rozman J, Klingenspor M, Hrabe de Angelis M, Valovka T, Huber L (2024). The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15). eLife, doi: 10.7554/elife.88350
  9. Nir R, Hoernes TP, Muramatsu H, Faserl K, Karikó K, Erlacher MD, Sas-Chen A, Schwartz S (2022). A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA. Nucleic Acids Res, doi: 10.1093/nar/gkac347
  10. Krasheninina OA, Thaler J, Erlacher MD, Micura R (2021). Amine-to-Azide Conversion on Native RNA via Metal-Free Diazotransfer Opens New Avenues for RNA Manipulations. Angew Chem Int Ed Engl, doi: 10.1002/anie.202015034
  11. Mikhaylina AO, Nikonova EY, Kostareva OS, Piendl W, Erlacher MD, Tishchenko SV (2021). Characterization of regulatory elements of L11 and L1 operons in thermophilic bacteria and archaea. Biochemistry (Mosc), doi: 10.1134/S0006297921040027
  12. Hoernes TP, Heimdörfer D, Köstner D, Faserl K, Nußbaumer F, Plangger R, Kreutz C, Lindner H, Erlacher MD (2019). Eukaryotic translation elongation is modulated by single natural nucleotide derivatives in the coding sequences of mRNAs. Genes, doi: 10.3390/genes10020084
  13. Hoernes TP, Faserl K, Juen MA, Kremser J, Gasser C, Fuchs E, Shi X, Siewert A, Lindner H, Kreutz C, Micura R, Joseph S, Höbartner C, Westhof E, Hüttenhofer A, Erlacher MD (2018). Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions. Nat Commun, doi: 10.1038/s41467-018-07321-8
  14. Hoernes TP, Clementi N, Juen MA, Shi X, Faserl K, Willi J, Gasser C, Kreutz C, Joseph S, Lindner H, Hüttenhofer A, Erlacher MD (2018). Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release. PNAS, doi: 10.1073/pnas.1714554115
  15. Safra M, Sas-Chen A, Nir R, Winkler R, Nachshon A, Bar-Yaacov D, Erlacher MD, Rosmanith W, Stern-Ginossar N, Schwartz S (2017). The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature, doi: 10.1038/nature24456
  16. Hoernes TP, Erlacher MD (2017). Methylated mRNA nucleotides as regulators for ribosomal translation. Methods Mol Biol, doi: 10.1007/978-1-4939-6807-7_19
  17. Schrode P, Huter P, Clementi N, Erlacher MD (2017). Atomic mutagenesis at the ribosomal decoding site. RNA Biol, doi: 10.1080/15476286.2016.1256637
  18. Hoernes TP, Erlacher MD (2017). Translating the epitranscriptome. Wiley Interdiscip Rev RNA, doi: 10.1002/wrna.1375
  19. Hoernes TP, Hüttenhofer A, Erlacher MD (2016). mRNA modifications: dynamic regulators of gene expression. RNA Biol, doi: 10.1080/15476286.2016.1203501
  20. Hoernes TP, Clementi N, Faserl K, Glasner H, Breuker K, Lindner H, Hüttenhofer A, Erlacher MD (2016). Nucleotide modifications within bacterial mRNAs regulate their translation and are able to rewire the genetic code. Nucleic Acids Res, doi: 10.1093/nar/gkv1182
  21. Koch M, Clementi N, Rusca N, Vögele P, Erlacher MD, Polacek N (2015). The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis. RNA Biology, doi: 10.1080/15476286.2015.1017221
  22. Erlacher MD, Polacek N (2012). Probing functions of the ribosomal peptidyl transferase center by nucleotide analog interference. Methods Mol Biol, doi: 10.1007/978-1-61779-545-9_14
  23. Erlacher MD, Chirkova A, Vögele P, Polacek N (2011). Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis. Nature Protocols, doi: 10.1038/nprot.2011.313
  24. Chirkova A, Erlacher MD, Clementi N, Zywicki M, Aigner M, Polacek N (2010). The role of the universally conserved A2450-C2063 base pair in the ribosomal peptidyl transferase center. Nucleic Acids Res, doi: 10.1093/nar/gkq213
  25. Wieland M, Berschneider B, Erlacher MD, Hartig J (2010). Aptazyme-Mediated Regulation of 16S Ribosomal RNA. Chemistry & Biology, doi: 10.1016/j.chembiol.2010.02.012
  26. Chirkova A, Erlacher MD, Micura R, Polacek N (2010). Chemically Engineered Ribosomes: A New Frontier in Synthetic Biology. Current Organic Chemistry, doi: 10.2174/138527210790069884
  27. Erlacher MD, Polacek N (2009). Role of RNA backbone groups for ribosomal catalysis. Biotechnologia
  28. Lang K, Erlacher MD, Wilson D, Micura R, Polacek N (2008). The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis. Chemistry & Biology, doi: 10.1016/j.chembiol.2008.03.014
  29. Erlacher MD, Polacek N (2008). Ribosomal catalysis: The evolution of mechanistic concepts for peptide bond formation and peptidyl-tRNA hydrolysis. RNA Biology, doi: 10.4161/rna.5.1.5636
  30. Amort M, Wotzel B, Bakowska-Zywicka K, Erlacher MD, Micura R, Polacek N (2007). An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination. Nucleic Acids Research, doi:10.1093/nar/gkm539
  31. Erlacher MD, Lang K, Wotzel B, Rieder R, Micura R, Polacek N (2006). Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2′-OH at A2451 of 23 S rRNA. Journal of the American Chemical Society, doi: doi.org/10.1021/ja0588454
  32. Erlacher MD, Lang K, Shankaran N, Wotzel B, Hüttenhofer A, Micura R, Mankin A, Polacek N (2005). Chemical engineering of the peptidyl transferase center reveals an important role of the 2′-hydroxyl group of A2451. Nucleic Acid Research, doi: doi.org/10.1093/nar/gki308